Frontiers

Genome Editing in Hepatocellular Carcinoma: Liver-Targeted Delivery and Immune Microenvironment Control

Hepatocellular carcinoma (HCC) is a leading cause of cancer-related death globally, with incidence continuing to rise in many regions. Despite advances in ...
C&EN

The Chemistry of Genome Editing: Transforming Human and Planet Health with CRISPR

I was born in Washington, DC, in 1964, the oldest of three sisters, but the place that truly formed me as a scientist was Hilo, on the Big Island of Hawaii. Growing up there, far from the mainland ...
EurekAlert!

Screening approach enhances CRISPR genome-editing efficiency

In research published today in Nucleic Acid Research, co-first author Seong Guk Park, PhD, and corresponding author Elizabeth Kellogg, PhD, St. Jude Department of Structural Biology, designed a ...
Frontiers

Expanding CRISPR Technologies in Underexplored Crops: Innovations and Applications

Non-model crop species represent a vast and diverse component of global agriculture, forestry, and horticulture, yet they are routinely underrepresented in ...
GEN

CHANGE-seq-BE Developed to Allow Scientists to Better Understand Base Editors

Scientists at St. Jude Children’s Research Hospital report that they have developed an unbiased, sensitive, and resource-efficient method to identify small, off-target sites that pose a safety risk ...
The Scientist

Getting to the Heart of CRISPR-Based Therapies

CRISPR-based therapy is a transformative approach to medicine that allows for targeted changes to the genome by directly addressing the source of disease, or to the epigenome through silencing of ...