Radiochemists can now expand their toolbox of molecular probes for positron emission tomography (PET), thanks to a new electrophilic fluorinating reagent. The palladium-based compound is made with 18 ...

Recently discovered electrophilic probes open the door to activity-based protein profiling (ABPP) studies of a broader range of proteins. It can be extremely challenging to study enzymes. Without any ...

In 2014, the European Medicines Agency approved the drug Tecfidera for the treatment of relapsing multiple sclerosis, a neurodegenerative disease that affects millions of people worldwide. In multiple ...

Recent studies show that redox-active small molecules are selectively cytotoxic to chronic lymphocytic leukemia (CLL). Although elevated levels of reactive oxygen species in CLL cells have been ...

Scientists generalize the synthesis of aminating agents to simplify the design and manufacture of drugs and other fine chemicals in which nitrogen atoms play key roles. Each of these agents contains ...