REISMAN, Zuelzer and Mitani 1 described polyploidy and endoreduplication of chromosomes in a patient being treated for acute leukemia. They ascribed these abnormalities to a primary chromosomal ...

The Fbw7/hCDC4 protein is the substrate specificity component of an Skp1–Cullin-F–Box ubiquitin ligase complex. Lesions in the Fbw7 gene have been observed in a large list of cancers (Moberg et al., ...

Scientists have discovered that endoreduplication, which promotes cellular enlargement in the epidermal tissue of Arabidopsis thaliana, occurs randomly as a Poisson process throughout cellular ...

CHAMPAIGN, Ill. -- Some plants behave like the mythical monster Hydra: Cut off their heads and they grow back, bigger and better than before. A new study finds that these "overcompensators," as they ...

Chemotherapeutics (e.g., aurora kinase inhibitors) designed to target proliferative cells are often nonspecific for tumor cells as normal cycling cells are also susceptible. Indeed, one of the major ...