How cancer cells die from chemotherapy: a new pathway. We have been treating cancer by damaging the DNA of tumor cells for over a hundred years, for example with radiation and che ...

Global proteomics and functional analyses reveal that p53-induced ZMAT3 suppresses mitochondrial respiration by inhibiting transcription of a hexokinase, uncovering a role for ZMAT3 in transcription.

A team of researchers at VCU Massey Comprehensive Cancer Center has identified a new pathway through which mutations in the tumor suppressor p53 gene—found very frequently in human tumors—hijack DNA ...

Researchers have elucidated the role of the p53 gene in ulcerative colitis. The study suggests a potential new drug target to stop disease progression to cancer. Researchers in the lab of Michael ...

Scientists have recently shed some light on exactly why elephants, one of the biggest animals on the planet, paradoxically experience unusually low rates of cancer. The research found these remarkable ...

Apoptosis, or programmed cell death, is a tightly regulated biological process necessary for normal tissue maintenance and development. However, aberrations in apoptotic signaling networks are ...

Cancer begins when mutations in specific genes override the body’s built-in controls on cell division, allowing rogue cells ...

After more than a decade of research, scientists have discovered the natural mechanism behind a novel form of cell death called ferroptosis. The work, described in the current issue of Cell, points ...