Inside every cell, thousands of molecular signals collide, overlap, and compensate, obscuring the true drivers of gene expression. Scientists have now developed a way to silence that cellular noise, ...

To support drug discovery, a new study has revealed fundamental features of the transcription cycle in the bacteria that causes tuberculosis.

A multi-institutional team of investigators have developed a catalog of transcription factor binding sites that regulate gene expression across the genome, according to a recent study published in ...

The Nuclear Factor I (NFI) family, comprising NFIA, NFIB, NFIC and NFIX, plays a pivotal role in coordinating developmental pathways and regulating gene expression throughout organogenesis. These ...

According to this model, sigma (σ) factors bind to RNA polymerase to initiate transcription—the process by which genetic information is copied from DNA to RNA—and then detach after initiation to allow ...

Research into transcription factors deepen understanding of the 'language' of the genome, offering insights into human development. New research has uncovered more about the complexity of human gene ...

Auckland, New Zealand-based GeneDetect.com has designed ODN decoys to more than 45 common transcription factors, with plans to release more. Each decoy is a double-stranded, synthetic phosphorothioate ...

A research group has revealed that transcription factors RUNX2 and BHLHE40 play crucial roles in inducing T cells involved in Crohn's disease. Crohn's disease is an intractable disorder characterized ...