NF-κB signalling is a central regulator of immune responses, orchestrating the expression of genes that control inflammation, cell survival and proliferation. T cell activation, triggered by antigen ...
NIK is the central regulator of the non-canonical NF-κB pathway, which is triggered by signaling from a subset of TNFR members. Upon receptor crosslinking by corresponding ligands, TRAFs and cIAP1/2 ...
For decades, scientists understood inducible nitric oxide synthase, or iNOS, as a one-trick enzyme. Its job was to churn out ...