TRIM28-mediated SUMOylation of ERG at K389 and its association with cell proliferation, PARP inhibitor response, and 53BP1 expression in castration-resistant prostate cancer. Heterogeneity and ...

This valuable study tested the impact of DNA methylation on CTCF binding in two cancer cell lines. Increased CTCF binding sites are enriched in gene bodies, and associate with nuclear speckles, ...

Greg Daugherty has worked 25+ years as an editor and writer for major publications and websites. He is also the author of two books. Katie Miller is a consumer financial services expert. She worked ...

“Our results suggest that rDNA promoter methylation and the age-related loss of active rDNA TU, which are a hallmark of the aging process, start only after reaching sexual maturity.” “Our results ...

We calculated the American Heart Association’s Life’s Essential 8 score to reflect CVH in 5 cohorts with diverse backgrounds (mean age 54 years, 55% women, and enrollment year ranging from 1989 to ...

The race for early cancer detection is one that physicians have been running for millennia. In one of humanity’s oldest surviving medical texts, the ancient Egyptian physician Imhotep described 46 ...

Abstract: Protein methylation is a fundamental post-translational modification(PTM) that plays critical roles in gene regulation, protein interactions, and cellular signaling pathways. However, ...

"We find that epigenetic clocks based on the entropy of methylation states predict chronological age with similar accuracy as common approaches that are based on methylation levels of individual ...

Researchers have developed the first comprehensive atlas of allele-specific DNA methylation across 39 human cell types, revealing a complex landscape of epigenetic regulation. The study identified ...

Altmetric provides a collated score for online attention across various platforms and media. See more details Epigenetic clocks that quantify rates of aging from DNA methylation patterns across the ...